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KMID : 0923620120120060277
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Immune Network
2012 Volume.12 No. 6 p.277 ~ p.283
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Vitamin C Up-regulates Expression of CD80, CD86 and MHC Class II on Dendritic Cell Line, DC-1 Via the Activation of p38 MAPK
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Kim Hyung-Woo
Cho Su-In
Bae Se-Yeon
Kim Hye-Min
Kim Ye-Jin
Hwang Young-Il
Kang Jae-Seung
Lee Wang-Jae
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Abstract
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Vitamin C is an essential water-soluble nutrient which primarily exerts its effect on host defense mechanisms and immune homeostasis, but the mechanism related to immune- potentiation is poorly understood. Since dendritic cells (DCs) are known as a potent antigen presenting cell (APC) that could enhance the antigen specific immune responses, we investigate the effects of vitamin C on activation of DCs and its related mechanism by using dendritic cell lines, DC-1. First, we found that there was no damage on DC-1 by 2.5 mM of vitamin C. In the presence of vitamin C, the expression of CD80, CD86, and MHC molecules was increased, but it was decreased by the pre-treatment of SB203580, p38 MAPK-specific inhibitor. We confirmed the phosphorylation of p38 MAPK was increased by the treatment of vitamin C. Taken together, these results suggest that vitamin C could enhance the activity of dendritic cells via the up-regulation of the expression of CD80, CD86, and MHC molecules and the activation of p38 MAPK is related to this process.
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KEYWORD
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Vitamin C, Dendritic cell, CD80, CD86, MHC class II, p38 MAPK
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